aashutosh.shetti@northwestern.edu
Tarry Building
PhD - University of Illinois Chicago
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Research Description
Aashu's research focuses on the role of Ca2+ in astrocyte function and how alterations in intracellular Ca2+ levels are associated with neuroinflammation. His work evaluates the ion channels, specifically Orai1, which regulate Ca2+ flow within cells and if genetic manipulations of these channels in astrocytes could prove beneficial in neurodegenerative diseases.
During his PhD, he studied the role of blood-brain barrier disruption in Type-2 Diabetes and how impairments in insulin trafficking into the brain can make the Type-2 diabetic brain vulnerable to Alzheimer's disease.