News and Announcements
Read the latest news from Northwestern University Feinberg School of Medicine’s Department of Pharmacology and learn more about our faculty’s latest achievements, awards and honors.
Northwestern Medicine investigators have developed a novel approach for designing and testing new protein folds, which could be used to develop new therapeutics.
Using machine learning, Northwestern scientists have demonstrated that the protein membrane CD81 interacts with CD44 in promoting tumor cell cluster formation and lung metastasis of triple negative breast cancer.
Therapeutically targeting ion channels in nociceptor neurons may be a promising strategy for managing osteoarthritis pain, according to a Northwestern Medicine study.
- 08.15.2022Alfred George, Jr., MD, is a pioneer in understanding the mechanisms by which ion channel mutations cause a variety of inherited disorders, such as genetic epilepsy. He discusses his recent breakthroughs in the field and his optimism for future RNA therapeutics to treat rare genetic diseases.
An immune system kinase promotes tumor inflammation and progression, according to a study published in Nature Communications.
Designed to target AMPAR receptors in the brain, the medication — called perampanel — also modulates kainate receptors.
An enzymatic modifier of messenger RNA has different functions depending on its location, according to a recent study.
A subunit of voltage-gated calcium channels was found to have a functional role in T-cells, according to a study published in Nature Communications.
- 04.27.2022Improving health equity and the impacts of pharmacogenetics were explored at the "Science and the City" symposium on April 6. The event was the second in a series jointly supported and developed by the Northwestern University Clinical and Translational Sciences (NUCATS) Institute and co-developed by the Chicago State University College of Pharmacy, Department of Pharmaceutical Sciences and Northwestern University Feinberg School of Medicine Department of Pharmacology.
Higher doses of anti-seizure medications may be necessary during pregnancy, according to a recent study.
A recent study published in Nature Genetics identified 10 new genetic regions associated with Brugada syndrome, a cardiac arrhythmia disorder.
Northwestern Medicine continues to help advance the understanding of the COVID-19 pandemic and its widespread impact, from investigating antibody protection against COVID-19 reinfection to elevating women in academic research to highlighting racial and ethnic disparities in COVID-19 hospital mortality in Illinois.
Northwestern Medicine scientists discovered functional links between dozens of potassium channel gene variants and neonatal epilepsy.
A team of Northwestern scientists led by Zhe Ji, PhD, assistant professor of Pharmacology and Biomedical Engineering, introduced a novel genomic experimental approach in ribosome profiling to study RNA translation. Traditional ribosome profiling technology uses RNase to digest RNA fragments and complicated procedures to isolate ribosome complexes, while the newly developed and simplified protocol uses low-input RNase footprinting to selectively quantify ribosome fragments more rapidly and effectively, according to the study published in the journal Genome Research. This scientific advance offers broad applications in both basic and clinical settings, particularly in situations where physiological samples are limited.
Sequencing known cardiac arrythmia genes in more than 20,000 people without an indication for genetic testing identified pathogenic variants in nearly one percent of individuals.
- 01.26.2022Northwestern University professors Paula H. Stern and Catherine Woolley have been selected 2021 fellows of the American Association for the Advancement of Science (AAAS).
A new study has identified naturally occurring nano-sized particles that can block infection from broad strains of SARS-CoV-2 virus in preclinical studies.
A team of investigators have discovered a novel genomic variant that may help clinicians predict which patients will experience cardiotoxicity from a widely used chemotherapy drug, according to a Northwestern Medicine study.
- 12.31.2021What do we know about the effectiveness of COVID-19 boosters, and how might they better protect us from new variants such as omicron? Alexis Demonbreun, PhD, assistant professor of Pharmacology, offers insight. She is the author of a new study that shows COVID-19 boosters seem to supercharge antibody response.
Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder.
Circulating tumor cells use the surface protein ICAM1 to strengthen stem cell programs and facilitate formation of tumor cell clusters, which can travel from primary tumors to other organs in the body.
In collaboration with Northwestern Medicine investigators, an international multi-center study has identified genetic factors associated with SARS-CoV-2 infection and COVID-19 severity.
Feinberg’s Department of Pharmacology has expanded in size, faculty, and research focus, and is looking ahead to future growth in the field.
Scientists discovered a previously unknown receptor site in a voltage-gated sodium channel, suggesting that a commonly-used cancer drug could be used to target this channel and relieve pain.
For the first time, Northwestern Medicine scientists have characterized how a genetic mutation associated with pediatric epilepsy affects neuron activity.
A team led by Northwestern Medicine investigators has identified a novel molecular target that may improve the efficacy of current treatments for triple-negative breast cancer.
Calcium channels commonly found in immune cells are also present in the brain and regulate synaptic plasticity, according to a recently published study.
Northwestern Medicine investigators have identified a novel “gate latch” mechanism within the Orai1 ion channel that is essential for proper activation of the immune system.
Northwestern scientists have determined how two protein mutations responsible for the impaired motor function in Parkinson’s disease independently disrupt neuron activity.