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Wayne Anderson, Ph.D.
Protein-nucleic Acid Interactions, DNA Polymerase, X-ray Crystallography, Structural Genomics
The Anderson laboratory's major focus is in structural genomics. The genome sequencing projects are producing a vast database of sequence information and provide a list of the proteins and their sequences that are used by that organism. ~~~Webpage|Publications~~~
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Douglas Freymann, Ph.D.
GTPase Structure and Regulation, X-ray Crystallography
The Freymann laboratory is studying the structural basis for regulation of the assembly and disengagement of these two GTPases, Ffh and FtsY ~~~Webpage|Publications~~~
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Adrian Gross, M.D.
Ion Channels: structure and function of membrane proteins
The Gross laboratoy studies the structure and function of ion channels, a family of membrane proteins that play many key roles in neuroscience and which are a major target of essential drugs used in clinical medicine.
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Xiaolin He, Ph.D.
Cell-surface Receptors in Development and Cancer
The He lab interest is understanding the structural mechanisms of signal transduction across the plasma membrane that control the development of cancer and neural system.
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Kouichi Iwasaki, Ph.D.
Molecular Biology and Genetics of a Rhythmic Behavior
The Iwasaki laboratory's goal is to understand the molecular and cellular mechanism of one biological rhythm, the digestive motor program (DMP) rhythm, using a model organism the nematode C. elegans. In the C. elegans experimental system, powerful genetic and molecular biological approaches are available.
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Hiroaki Kiyokawa, Ph.D.
Roles of cell cycle-regulatory protein in differentiation, senescence and tumorgenesis; cell cycle control in endocrine and reproductive organs
The Kiyokawa laboratory studies molecular events determining cell fate are initiated during the G1 phase of the cell cycle.
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Liming Li, Ph.D.
Molecular Mechanisms of Protein Conformation-based Infectivity and Inheritance
The Li laboratory is interested in studying prion phenomenon using yeast as a model organism. Yeast offers a powerful system that is amenable to biochemical, cell biological and genetic manipulations.
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Richard Miller, Ph.D.
Molecular Pharmacology of Receptors, Signal Transduction and Synaptic Transmission. Regulation of Neuronal Receptors and Ion Channels. Molecular Aspects of Nerve Cell Degeneration.
The Miller laboratory is concerned with understanding molecular aspects of synaptic communication under normal circumstances and also under pathological conditions.
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Toshio Narahashi, Ph.D.
Ion Channel Pharmacology
The Narahashi laboratory is engaged in extensive studies of nerve membrane ion channels using advanced electrophysiological techniques such as whole-cell and single-channel patch clamp.
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Murali Prakriya, Ph.D.
Calcium Signaling Mechanisms in Health and Disease
The Prakriya laboratory is focused on calcium signaling mechanisms involving store-operated channels (SOCs). SOCs are a family of Ca2+ permeable ion channels expressed by most cells.
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Eugene Silinsky, Ph.D.
Mechanisms of synaptic transmission, neurotransmitter release and its modulation by adenosine; Ligand-gated channels and their interactions
The Silinsky laboratory interests are studying the presynaptic and postsynaptic mechanisms underlying chemical synaptic transmission with emphasis on the processes which co-released adenosine derivatives modulate excitatory synaptic transmission.
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Paula Stern, Ph.D.
Signaling in Bone Cells
The Stern laboratory interests are in bone cell biology/endocrine pharmacology. The maintenance of bone involves a delicate balance between the actions of systemic hormones, local cytokines and growth factors, and physical forces.
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Geoffrey Swanson, Ph.D.
Isolation and characterization of new marine-derived compounds that target glutamate receptors
The Swanson laboratory studies the molecular and physiological properties of receptor proteins that underlie excitatory synaptic transmission in the mammalian brain.
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D. Martin Watterson, Ph.D.
Calmodulin-mediated Signal Transduction; Genetic, Cell Biology and Biophysical Approaches
The Watterson laboratory works on the elucidation of eukaryotic cell signal transduction pathways, their role in vertebrate cell function and pathophysiology, and the use of this knowledge of structure, function and mechanism to identify potential therapeutic targets and develop novel therapeutics.
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Jay Yeh, Ph.D.
Sodium Channels and GABA activated Chloride Channels; biophysics and Pharmacology
The Yeh laboratory interest included biophysics and pharmacology of both Na channels and GABA-activated chloride channels with emphases on the molecular mechanism by which local anesthetics and anticonvulsant drugs interact with the Na channel and the molecular mechanisms by which volatile general anesthetics interact with the GABAA receptor CI channel.
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Ming Zhang, Ph.D.
Molecular Mechanisms of Tumorigenesis and Cancer Metastasis
The Zhang laboratory studies breast and prostate cancer progression. Our starting point is a gene named MASPIN, a unique member of SERPIN family that plays roles in normal tissue development, tumor metastasis, and angiogenesis.
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